Overview
Position Summary:
The Shawber laboratory at Columbia University Irving Medical Center (CUIMC) is seeking a self-motivated postdoctoral scientist to join an energetic, collaborative and goal-oriented team whose research is focused on understanding genetic regulation of lymphatic development and homeostasis and its role in human pathologies, including primary lymphatic anomalies, fat disorders, and liver disease. The Shawber group uses a combination of in vitro cell culture systems, conditional transgenic models, and xenograft models with both engineered and patient-derived lymphatic endothelial cells to understand the genes that regulate lymphatic development and maintenance. The Shawber lab is currently supported by NIH and Foundation funding. CUIMC among the top tier of the nation’s medical schools in research funding offers a highly interactive and stimulating academic environment for scientists in training.
Candidates with a PhD, or MD/PhD and a background in molecular biology, developmental biology, vascular biology, and/or molecular genetics are encouraged to apply. The open research project is focused on validating genes and variants of uncertain significance identified in a multi-institutional genomic study of primary lymphatic anomalies. The project involves recombinant DNA, CRISPR/CAS, protein evaluation, use of viral vectors, and primary human tissue culture. Experience in DNA engineering (PCR, site-directed, CRISPR/CAS) and cell biology methodologies is preferred. The postdoctoral scientist will work independently under the mentorship of Dr. Shawber, and will lead all experimentation, analysis, and publication of research. They will be encouraged to apply for independent funding and present their research at national and international meetings. The postdoctoral scientist will also have the opportunity to participate in a consortium led by Dr. Shawber of international researchers with expertise in zebrafish, genomic bioinformatics, geneticists, cell biologists, and perinatal clinical care.
Responsibilities:
The postdoctoral scientist will work independently under the mentorship of Dr. Shawber, and will lead in the experimentation, analysis, presentation and publication of research. They will be encouraged to apply for independent funding and present their research at national and international meetings. Candidates will also be responsible for generating monthly research reports for funder.
Minimum Qualifications:
· A doctoral degree in molecular biology, developmental biology, vascular biology, molecular genetics, cell biology or related field.
Preferred Qualifications:
· Extensive experience in molecular cloning
· Extensive experience in primary human cell culture
· Experience in cell biology methodologies
· CRISPR/CAS
Application Instructions:
To be considered for this opportunity, please send a cover letter and CV to Dr. Carrie Shawber at cjs2002@cumc.columbia.edu.
Equal Employment Opportunity Statement
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Pay Transparency Disclosure
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting.
